59.Proto-oncogenes can be converted to oncogenes by various genetic changes. Which of these mechanisms does not contribute to an abnormal cell cycle?
(A)A gene is transposed to a more active promoter.
(B)Chromosomes break and fragments are translocated from one chromosome to another.
(C)Point mutations occur that result in a protein more resistant to degradation.
(D)Extra copies of the gene are made, thereby enhancing expression.
(E)DNA methylation takes place.