61. 下列的敘述何者有誤?
(A) Tramadol 同時兼具有inhibition of noradrenaline reuptake 及opioid agonist effects
(B) Naloxone is a nonselective antagonist at all three (u, δ, κ) receptors
(C) 當施行epidural block 若產生遲發性(a delay of 15 to 30 minutes ) 且 higher than expected block develops 時 intrathecal subdural placement of local anesthetic must be considered.
(D) Opioid tolerance to respiratory depression, sedation, and nausea often develops faster than tolerance to constipation or miosis
(E) Selective COX-2 inhibitors confer an increased risk for thrombosis, myocardial infarction, renal impairment, hypertension, stroke, and liver toxicity。