(B)For people without heart disease, taking a daily aspirin to prevent heart attacks andstrokes may increase the risk of severe brain bleeding to the point where it outweighs anypotential benefit, a research review suggests.    U.S. doctors have long advised adults who haven't had a heart attack or stroke but are athigh risk for these events to take a daily aspirin pill, an approach known as primaryprevention. __61___ there's clear evidence aspirin works for this purpose, many physiciansand patients have been reluctant to follow the recommendations because of the risk of rarebut potentially lethal internal bleeding.    For the current study, researchers examined data from 13 clinical trials testing the effectsof aspirin __62___ a placebo or no treatment in more than 134,000 adults. The risk ofintracranial hemorrhage, or brain bleeds, was rare.    One limitation of the analysis is that the smaller clinical trials examined a variety ofaspirin doses up to 100 milligrams daily. The analysis also only focused on brain bleeds, andnot on other types of internal bleeding associated with aspirin. ___63___ the benefits forpreventing heart attacks, the consensus on aspirin has changed over time, particularly forpeople without heart disease or hardening and narrowing of the arteries.    "We have previously recommended aspirin to prevent platelets from __64___ the insideof an individual's arteries, but the benefit, while real, turns out to be small compared to therare but devastating incidence of brain hemorrhage," the researcher said. "We no longerrecommend routine use of aspirin in individuals who have no demonstrable cardiovasculardisease or atherosclerosis."
61.
(A) On the contrary
(B) For the most part
(C) Without a doubt
(D) Even though