Which statement is least likely：
(A) Administering morphine at the end of surgery (1 to 3 mg ,i.v., every 5 ~ 10 minimproves pain relief with less respiratory depression
(B) The presnce of pain prevent respiratory depression
(C) Patient-controlled analgesia minimizes patient anxiety
(D) NSAID can be part of an effective multimodal analgesia protocol
(E) In general, thoracotomy appears to be the most painful operation