66. The high free energy change for the hydrolysis of a thiol ester, as found in acetyl-CoA, compared with that for thehydrolysis of a simple ester, is partly due to __________.
(A) the greater resonance stability in a simple ester due to better π-electron overlap in a CO linkage than in a CS linkage
(B) the gain in resonance energy in the product, acetate
(C) the high value for the bond energy in S-C bond
(D) reduction of the unfavorable electrostatic interaction in the acetyl-CoA
(E) the high value for the bond energy in S-P bond