60. 影響小兒區域麻醉的因素，何者不正確？
(A)Increased cardiac output and heart rate, Increased systemic absorption of local anesthetic
(B)Increased extracellular fluids, decreased Cmax after single injection but accumulation with repeat/continuous injections
(C)Loose attachment of sheaths and aponeuroses to underlying structures, smaller volume of local anesthetic is required for epidural blocks due to leakage along spinal nerve roots.
(D)Enzymatic immaturity, increased mean body residency time and half-life
(E)Lack of fusion of sacral vertebrae, Intervertebral sacral epidural approaches can be performed throughout childhood.