45.以電腦分子模擬（molecular modeling）進行藥物設計，若受體（receptor）與配體（ligand）之3D立體結構均已知，則下列何種方法最適合？
(A)Combinatorial-based approach
(B)De Novo design-based approach
(C)DOCK receptor-based approach
(D)Ligand-based approach